Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
January 20, 2005AJP Cell Physiology

Skeletal muscle contractile performance and ADP accumulation in adenylate kinase-deficient mice

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does adenylate kinase deficiency affect skeletal muscle contractile performance and ADP accumulation in mice?

Population

Adenylate kinase 1 deficient (AK1-/-) mice and wild-type (WT) controls

Comparison

Adenylate kinase 1 deficiency (AK1-/-) vs Wild-type (WT) controls

Design

Preclinical

Authors

CHChad R. HancockBrigham Young UniversityEJEdwin JanssenTarget (United States)RTRonald L. TerjungUniversity of Missouri

Discussion

Loading...

Member takes

Implication

AK1 deficiency impairs ADP buffering and relaxation in murine muscle; hypothesis-generating for human myopathies, should not yet change practice.

Structured PICO

Does adenylate kinase deficiency affect skeletal muscle contractile performance and ADP accumulation in mice?

P
Population
Adenylate kinase 1 deficient (AK1-/-) mice and wild-type (WT) controls
I
Intervention
Adenylate kinase 1 deficiency (AK1-/-)
C
Comparator
Wild-type (WT) controls
O
Outcome
Isometric tetanic contractile performance of the gastrocnemius-plantaris-soleus (GPS) muscle group in situ over a range of contraction frequencies (30-120 tetani/min) and adenine nucleotide management (ADP accumulation, IMP formation rate)surrogate

Adenylate kinase deficiency in mice leads to significant ADP accumulation and slowed relaxation kinetics at high energy demands, though overall muscle fatigue patterns remain similar to wild-type.

Cite This Study

Hancock et al. (2005) studied this question.

synapsesocial.com/papers/6a7156e1660549caf2c5f804https://doi.org/10.1152/ajpcell.00567.2004
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of physiological ADP concentrations on contraction of single skinned fibers from rabbit fast and slow muscles1995 · 102 citations
  2. 2Effect of an ADP analog on isometric force and ATPase activity of active muscle fibers2003 · 32 citations
  3. 3Muscle function during repetitive moderate-intensity muscle contractions in myoadenylate deaminase-deficient Dutch subjects2002 · 28 citations
  4. 4ADP dissociation from actomyosin subfragment 1 is sufficiently slow to limit the unloaded shortening velocity in vertebrate muscle.1985 · 416 citations
  5. 5Metabolic changes associated with the slowing of relaxation in fatigued mouse muscle.1975 · 181 citations