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December 1, 2000Journal of Biological ChemistryOpen Access

Under hypoxia, AK1-deficient hearts had a blunted AK-catalyzed phosphotransfer response, lowered intracellular ATP levels, increased P(i)/ATP ratio, and suppressed generation of adenosine compared with wild type.

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Population

Hearts with a null mutation of the AK1 gene (AK1 knockout) and wild type hearts

Comparison

Metabolic stress (hypoxia) vs Wild type hearts under hypoxia; absence of…

Design

Preclinical

Authors

DPDarko PucarEJEdwin JanssenPDPetras P. Dzeja

Discussion

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Overview

AK1 supports hypoxic myocardial energetics in mice; leaves open human relevance and therapeutic targeting.

Structured PICO

P
Population
Hearts with a null mutation of the AK1 gene (AK1 knockout) and wild type hearts
I
Intervention
Metabolic stress (hypoxia)
C
Comparator
Wild type hearts under hypoxia; absence of metabolic stress
O
Outcome
Phosphotransfer dynamics, intracellular ATP levels, P(i)/ATP ratio, and adenosine generationsurrogate

The AK1 gene is essential for maintaining myocardial energetic homeostasis and cardioprotective signaling under metabolic stress such as hypoxia.

Cite This Study

Pucar et al. (2000) studied this question.

synapsesocial.com/papers/6a82a13550b6b35c4f8adecchttps://doi.org/10.1074/jbc.m007903200
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Common Variant in AMPD1 Gene Predicts Improved Clinical Outcome in Patients With Heart Failure1999 · 129 citations
  2. 2THE CREATINE-CREATINE PHOSPHATE ENERGY SHUTTLE1985 · 760 citations
  3. 3Adenylate Kinase-catalyzed Phosphoryl Transfer Couples ATP Utilization with Its Generation by Glycolysis in Intact Muscle1995 · 113 citations
  4. 4Evidence for compartmentalized adenylate kinase catalysis serving a high energy phosphoryl transfer function in rat skeletal muscle.1990 · 92 citations
  5. 5Myocardial Phosphocreatine-to-ATP Ratio Is a Predictor of Mortality in Patients With Dilated Cardiomyopathy1997 · 751 citations