Key result
Muscle AMPD deficiency does not affect exercise performance or energy metabolism during exhaustive exercise.
Why the study?
The role of the purine nucleotide cycle in TCA cycle anaplerosis during exercise is debated, and AMPD1 mutation carriers provide a human model to investigate this.
Does myoadenylate deaminase deficiency affect muscle anaplerosis or exercise performance during exhaustive exercise in humans?
Observational (n=19)
Does myoadenylate deaminase deficiency affect muscle anaplerosis or exercise performance during exhaustive exercise in humans?
Myoadenylate deaminase deficiency does not impair TCA cycle anaplerosis or exercise performance during exhaustive exercise in humans.
No takes yet. Share an insight, caveat, or question.
AMPD deficiency does not impair TCA anaplerosis or performance; leaves open PNC role in anaplerosis and should not change practice.
Tarnopolsky et al. (2001) conducted an observational in Myoadenylate deaminase (AMPD) deficiency (n=19). AMPD1 mutation (AMPD deficiency) vs. Normal AMPD activity (+/+ genotype) was evaluated on Time to exhaustion and TCA cycle anaplerosis. Complete and partial muscle AMPD deficiency did not affect TCA cycle anaplerosis, phosphocreatine hydrolysis, energy charge, or exercise performance during exhaustive exercise.
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