Key result
AMPD1 CC genotype appears more frequently in rowers than controls, presenting in ~88% of athletes.
Why the study?
The association between the C34T polymorphism of the AMPD1 gene and athlete performance in rowing was unclear.
Is the C34T polymorphism of the AMPD1 gene associated with athletic performance in rowers?
Case-Control (n=378)
Is the C34T polymorphism of the AMPD1 gene associated with athletic performance in rowers?
Absolute Event Rate: 88.19% vs 75.31%
p-value: p=0.009
The T allele of the AMPD1 gene C34T polymorphism is significantly less frequent in elite rowers, suggesting it may act as a negative factor for athletic performance.
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AMPD1 C34T differences in rowers suggest performance association; hypothesis-generating and requires replication.
Cięszczyk et al. (2011) conducted a case-control in Athlete performance in rowing (n=378). AMPD1 gene C34T polymorphism vs. Unrelated volunteer controls was evaluated on CC genotype frequency (p=0.009). The AMPD1 C34T polymorphism CC genotype was more frequent in rowers than controls (88.19% vs 75.31%, p=0.009), with a significant deficiency of the T allele in athletes.
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