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March 1, 1995Journal of Biological ChemistryOpen Access

Adenylate Kinase-catalyzed Phosphoryl Transfer Couples ATP Utilization with Its Generation by Glycolysis in Intact Muscle

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Population

Intact, isolated rat diaphragm

Design

Preclinical

Authors

RZRobert J. ZeleznikarPDPetras P. DzejaNGNelson D. Goldberg

Discussion

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Overview

May support muscle energetics under stress in animals; leaves open relevance to human cardiac bioenergetics.

Structured PICO

P
Population
Intact, isolated rat diaphragm
I
Intervention
Altered anaerobic and aerobic ATP production (via stimulated contractile frequency, O2 deprivation, or treatment with KCN or p-(trifluoromethoxy)-phenylhydrazone)
O
Outcome
Rates of phosphoryl transfer catalyzed by adenylate kinase (assessed by determining rates of AMP phosphorylation with endogenously generated [gamma-18O]ATP)surrogate

Adenylate kinase-catalyzed phosphotransfer is coupled to ATP generation by anaerobic glycolysis in skeletal muscle, particularly when oxidative phosphorylation is impaired.

Cite This Study

Zeleznikar et al. (1995) studied this question.

synapsesocial.com/papers/6a855cdd581d4f62e2d59a10https://doi.org/10.1074/jbc.270.13.7311
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Suppression of Creatine Kinase-catalyzed Phosphotransfer Results in Increased Phosphoryl Transfer by Adenylate Kinase in Intact Skeletal Muscle1996 · 100 citations
  2. 2Evidence for compartmentalized adenylate kinase catalysis serving a high energy phosphoryl transfer function in rat skeletal muscle.1990 · 92 citations
  3. 3Adenylate Kinase–Catalyzed Phosphotransfer in the Myocardium1999 · 209 citations
  4. 4Specific enhancement of the cardiac myofibrillar ATPase by bound creatine kinase.1992 · 63 citations
  5. 5The Critical Role of Adenylate Kinase in Regulating the Glycolysis Rate in Cells2026 · 1 citations