Key result
Chronic isoproterenol administration induced greater impairments in contractile reserve and greater increases in cardiac hypertrophy (LV index: 33% vs 22%) in mature adult rats compared to young adult rats.
Why the study?
Does chronic isoproterenol administration impair contractile reserve more in mature adult rats compared to younger adult rats?
Population
Nonsenescent, mature adult rats and younger adult rats
Comparison
Daily injections of isoproterenol for 3 weeks vs Vehicle injections for 3 weeks
Design
Preclinical
Follow-up
3 weeks
Authors
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Hypothesis-generating for age-dependent catecholamine susceptibility in adulthood; leaves open human relevance.
Does chronic isoproterenol administration impair contractile reserve more in mature adult rats compared to younger adult rats?
Absolute Event Rate: 33% vs 22%
Chronic catecholamine excess induces greater impairments in systolic performance and cardiac hypertrophy in mature adult rats compared to younger adult rats, indicating age-related susceptibility occurs earlier in life.
Liles et al. (2011) studied Cardiac hypertrophy. Isoproterenol (ISO) vs. Vehicle and young adult ISO-treated rats was evaluated on Contractile reserve (maximum of left ventricular pressure development) and cardiac hypertrophy (LV index). Chronic isoproterenol administration induced greater impairments in contractile reserve and greater increases in cardiac hypertrophy (LV index: 33% vs 22%) in mature adult rats compared to young adult rats.
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