Primary structure and topological analysis of a skeletal muscle-specific junctional sarcoplasmic reticulum glycoprotein (triadin)

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Population

Skeletal muscle (with comparison to cardiac muscle and brain)

Design

Preclinical

Authors

Discussion

Triadin's skeletal muscle specificity indicates no role in cardiac excitation-contraction coupling; leaves open identification of cardiac analogs.

Population

Skeletal muscle (with comparison to cardiac muscle and brain)

Intervention

cDNA sequencing, biochemical analysis, protease analysis, Western and Northern blots

Outcome

Primary amino acid sequence, topological structure, and tissue expression specificity of triadin

Identifies the primary structure and topology of triadin, a skeletal muscle-specific glycoprotein likely involved in excitation-contraction coupling.

Knudson et al. (1993) studied this question.

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Triadin's skeletal muscle specificity indicates no role in cardiac excitation-contraction coupling; leaves open identification of cardiac analogs.