Why the study?
Does triadin knockout alter excitation-contraction coupling and intracellular Ca2+ homeostasis in skeletal muscle?
Population
Pan-triadin-null mice engineered by removing the first exon of the triadin gene
Comparison
Triadin gene knockout vs Wild-type mice
Design
Preclinical
Authors
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Triadin knockout alters skeletal Ca2+ handling in mice without blocking EC coupling; hypothesis-generating for its cardiac role and leaves clinical translation open.
Does triadin knockout alter excitation-contraction coupling and intracellular Ca2+ homeostasis in skeletal muscle?
Triadin is not essential for skeletal-type excitation-contraction coupling but plays an indirect role in regulating myoplasmic Ca2+ homeostasis and organizing the molecular complex of the triad.
Shen et al. (2007) studied this question.
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