Key result
Myofibroblasts induced synchronized spontaneous activity in cultured ventricular cardiomyocyte strands in a density-dependent manner, whereas uncoated strands remained quiescent.
Myofibroblasts can induce depolarization-induced abnormal automaticity in cardiomyocytes via heterocellular electrotonic interactions, suggesting a mechanism for arrhythmogenesis in fibrotic remodeled myocardium.
No takes yet. Share an insight, caveat, or question.
May implicate myofibroblast coupling in fibrotic arrhythmias; hypothesis-generating pending in vivo validation.
Miragoli et al. (2007) studied Arrhythmogenesis. Myofibroblast coating vs. Uncoated cardiomyocyte strands was evaluated on Synchronized spontaneous activity. Myofibroblasts induced synchronized spontaneous activity in cultured ventricular cardiomyocyte strands in a density-dependent manner, whereas uncoated strands remained quiescent.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: