Key result
Coupling of myocytes to myofibroblasts promoted early afterdepolarization formation that could not be suppressed by rapid pacing, driven by an early transient-outward Ito-like current.
Why the study?
Does myofibroblast-myocyte coupling promote early afterdepolarizations in adult rabbit ventricular myocytes?
Does myofibroblast-myocyte coupling promote early afterdepolarizations in adult rabbit ventricular myocytes?
Myofibroblast-myocyte coupling promotes early afterdepolarizations via an Ito-like gap junction current, providing a cellular mechanism for arrhythmogenesis in fibrotic hearts.
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Myofibroblast-myocyte coupling may promote EADs; hypothesis-generating for fibrotic arrhythmogenesis with clinical relevance untested.
Nguyen et al. (2011) studied Cardiac arrhythmias. Myofibroblast-myocyte coupling vs. Absence of myofibroblast-myocyte coupling was evaluated on Early afterdepolarizations (EADs) formation during rapid pacing. Coupling of myocytes to myofibroblasts promoted early afterdepolarization formation that could not be suppressed by rapid pacing, driven by an early transient-outward Ito-like current.