Key result
Sleep deprivation triggers autonomic brain activity strongly linked to lower amyloid beta burden.
Why the study?
The relevance of interactions between autonomic and central nervous systems for human brain function and health remains unclear, particularly when challenged under sleep deprivation.
Does sleep deprivation alter synchronized brain activity and autonomic-central interactions in healthy participants?
Population
Healthy participants
Comparison
Sleep deprivation vs rested wakefulness
Authors
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Suggests autonomic synchronization during sleep deprivation may aid amyloid clearance; leaves open clinical relevance for Alzheimer's risk.
Observational
Does sleep deprivation alter synchronized brain activity and autonomic-central interactions in healthy participants?
Standardized Mean Difference: 0.8
Sleep deprivation triggers an autonomic mode of synchronized brain activity that correlates with distinct autonomic-central interactions and is associated with lower amyloid beta burden, highlighting relevance to brain clearance mechanisms.
Shokri‐Kojori et al. (2023) conducted an observational in Healthy. Sleep deprivation vs. Rested wakefulness was evaluated on Association between low frequency power of an autonomically-related network and amyloid beta burden (Cohen's d 0.8). Sleep deprivation triggered an autonomic mode of synchronized brain activity, where higher low frequency power was associated with lower amyloid beta burden (Cohen's d = 0.8).
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