Key result
Large and compound asymptomatic, nonstenotic carotid ulcers were associated with hemispheric stroke rates of 21% and 19% respectively over up to 10 years, compared to 3% for small ulcers.
Why the study?
What is the natural history and stroke risk of asymptomatic, nonstenotic ulcerative lesions of the carotid artery?
Population
141 patients with 153 asymptomatic, nonstenotic ulcerative lesions of the carotid bifurcation
Design
Cohort
Follow-up
up to ten years
Authors
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Large asymptomatic carotid ulcers may elevate stroke risk; extends natural history data but leaves open intervention benefit.
Cohort (n=141)
What is the natural history and stroke risk of asymptomatic, nonstenotic ulcerative lesions of the carotid artery?
Absolute Event Rate: 21% vs 3%
Large and compound asymptomatic, nonstenotic carotid ulcers carry a high annual stroke risk (4.5-7.5%), comparable to symptomatic patients, suggesting a potential benefit for prophylactic surgery.
Sherwood M. Dixon (1982) conducted a cohort in Asymptomatic, nonstenotic ulcerative lesions of the carotid artery (n=141). Large (B) and compound (C) carotid ulcers vs. Small (A) carotid ulcers was evaluated on Hemispheric strokes without antecedent transient ischemic attacks (TIAs) on the side appropriate to the lesion. Large and compound asymptomatic, nonstenotic carotid ulcers were associated with hemispheric stroke rates of 21% and 19% respectively over up to 10 years, compared to 3% for small ulcers.
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