What question did this study set out to answer?

To investigate the enzymes and coagulation properties of isolated human platelet components for better understanding.

January 1, 1966Journal of Clinical InvestigationOpen Access

Studies on human platelet granules and membranes.

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Population

Human platelets isolated from 425 ml of whole blood obtained from a fasting donor with a normal platelet…

Design

Preclinical

Authors

AMAaron J. MarcusCornell University DZD Zucker-FranklinColumbia University Irving Medical Center LSL B SafierNewYork–Presbyterian Hospital

Discussion

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Implication

Granule enzyme mapping advances platelet biology models; leaves open translation to human thrombosis.

Key Points

To investigate the enzymes and coagulation properties of isolated human platelet components for better understanding.
Isolated subcellular components of human platelets were analyzed.
Enzymatic activity and coagulation properties were examined in detail.
Identified various enzymes in isolated platelet components.
Uncovered unknown biochemical substances associated with platelet functions.

Structured PICO

Population

Human platelets isolated from 425 ml of whole blood obtained from a fasting donor with a normal platelet count.

Intervention

Subcellular fractionation using homogenization and continuous sucrose density gradient ultracentrifugation.

Outcome

Enzyme activities (cytochrome c oxidase, acid phosphatase, beta-glucuronidase, cathepsin, catalase, lactic dehydrogenase) and coagulation properties of isolated subcellular platelet components.surrogate

This basic science study demonstrates the successful isolation of human platelet granules and membranes and characterizes their specific enzymatic and coagulation properties.

Cite This Study

Marcus et al. (1966) studied this question.

synapsesocial.com/papers/6a2155f0589de9df3302f339 https://doi.org/10.1172/jci105318

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Studies on human platelet granules and membranes.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Studies on human platelet granules and membranes.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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