Key result
High-resolution 2-DE proteome mapping of human platelets identified approximately 2300 protein features, including 284 proteins from 123 open reading frames in the 4-5 pI range.
Population
Human platelets
Design
Preclinical
Authors
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Advances platelet proteome resources; leaves open therapeutic targeting in thrombosis pending validation.
This proteomic mapping of human platelets provides a foundational basis for understanding platelet biology and identifying future drug targets for thrombotic diseases.
O’Neill et al. (2002) studied this question. Proteomic analysis was evaluated on Identification of platelet proteins. High-resolution 2-DE proteome mapping of human platelets identified approximately 2300 protein features, including 284 proteins from 123 open reading frames in the 4-5 pI range.
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