Key result
Proteomic analysis of the pI 5-11 region of the human platelet proteome identified 760 protein features corresponding to 311 different genes, annotating 54% of the 2-DE proteome map.
Population
Human platelets
Design
Preclinical
Authors
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Extends the platelet proteome map; leaves open whether identified proteins represent actionable drug targets.
This proteomic analysis extends the known human platelet proteome map, identifying 311 genes primarily involved in intracellular signaling and cytoskeleton regulation to aid future drug target discovery.
García et al. (2004) studied this question. Proteomic analysis (2-DE and MS/MS) was evaluated on Identification of protein features in the pI 5-11 region of the human platelet proteome. Proteomic analysis of the pI 5-11 region of the human platelet proteome identified 760 protein features corresponding to 311 different genes, annotating 54% of the 2-DE proteome map.
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