Key result
Isoflavone supplementation did not potentiate the reductions in resting and ambulatory blood pressure achieved by 10 weeks of combined aerobic and resistance training in non-obese postmenopausal women.
Why the study?
Physical exercise and isoflavones are potential strategies to prevent and treat CVD in postmenopausal women, but whether isoflavone supplementation provides additive effects when combined with aerobic and resistance exercise on BP and BPV was unknown.
Does isoflavone supplementation reduce ambulatory blood pressure in non-obese postmenopausal women undergoing combined exercise training?
RCT (n=38)
Double-blind
electronic draw program
No
Does isoflavone supplementation reduce ambulatory blood pressure in non-obese postmenopausal women undergoing combined exercise training?
Isoflavone supplementation provides no additive blood pressure-lowering benefit to combined aerobic and resistance training in healthy postmenopausal women.
No additive BP benefit from isoflavone with exercise in postmenopausal women; confirms lack of potentiation and supports exercise alone.
Physical exercise and isoflavone supplementation are potential strategies to prevent and treat cardiovascular diseases in postmenopausal women. The aim of this study was to investigate whether there are additive effects of isoflavone supplementation when associated with combined aerobic and resistance exercise on resting and ambulatory blood pressure monitoring (ABPM) and in blood pressure variability (BPV). Thirty-one non-obese postmenopausal women were randomly allocated into two groups: placebo and exercise (Placebo n = 19); and isoflavone supplementation (100 mg/day) and exercise (isoflavone n = 19). ABPM and BPV were evaluated before and after 10 weeks of moderate combined (aerobic and resistance) exercise training. Generalized Estimating Equation (GEE) with Bonferroni correction and intention-to-treat analysis was used to compare the effects of interventions on resting BP, ABPM and BPV. Combined exercise training decreased resting systolic (SBP) and diastolic blood pressure (DBP) and reduced 24 h and awake ambulatory SBP, DBP and mean blood pressure over time, with no additional effects of isoflavone supplementation. No changes were observed in sleep period, or in BPV indexes (Standard Deviation of 24 h (SD), daytime and nighttime interval (SDdn) and average real variability (ARV) in both groups. We conclude that isoflavone supplementation does not potentiate the effects of combined training on resting and ambulatorial systolic and diastolic blood pressure in non-obese postmenopausal women.
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Costa et al. (2020) conducted an RCT in Non-obese postmenopausal women (n=38). Isoflavone supplementation vs. Placebo was evaluated on Blood pressure response assessed by ambulatory blood pressure monitoring (ABPM). Isoflavone supplementation did not potentiate the reductions in resting and ambulatory blood pressure achieved by 10 weeks of combined aerobic and resistance training in non-obese postmenopausal women.
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