Mitochondrial genetics influences degenerative diseases in aging populations, suggesting new therapeutic avenues.
Studies of diseases caused by mitochondrial DNA mutations suggest that a variety of degenerative processes may be associated with defects in oxidative phosphorylation (OXPHOS). Application of this hypothesis has provided new insights into such diverse clinical problems as ischemic heart disease, late-onset diabetes, Parkinson's disease, Alzheimer's disease, and aging.
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Douglas C. Wallace (1992) studied this question.
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