What question did this study set out to answer?

To delineate the molecular mechanisms of mitochondrial dysfunction in aging, describe its role as an inter-organ communication hub, and evaluate emerging therapeutic strategies.

August 19, 2026Gerontology

Mitochondrial Dysfunction as a Central Hub of Aging: From Molecular Cascades to Inter-Organ Communication Networks

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Authors

CHChaodong HanLiaocheng People's Hospital ZZZilian Zhang YSYafeng SongChina Institute of Sport Science

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Implication

Narrative review reveals mitochondrial signaling cascades drive systemic aging across multiple organ axes, highlighting therapeutic targets for extending healthspan.

Key Points

To delineate the molecular mechanisms of mitochondrial dysfunction in aging, describe its role as an inter-organ communication hub, and evaluate emerging therapeutic strategies.
Narrative synthesis examining molecular pathways of mitochondrial decline, including reactive oxygen species imbalance, mtDNA damage, defective mitophagy, and metabolic reprogramming.
Review of inter-organ signaling networks and potential interventions ranging from NAD+ precursors to mitochondrial transplantation and gene editing.
Mitochondria drive systemic aging by secreting mitokines (FGF21, GDF15) and releasing damage-associated molecular patterns (DAMPs) that activate cGAS-STING and NLRP3 inflammasome inflammatory cascades.
Inflammatory signaling from dysfunctional mitochondria disrupts communication along key physiological networks, including the skeletal muscle–brain and adipose/liver–cardiovascular axes.
Targeted interventions improve mitochondrial function in animal models, but human clinical translation remains limited by evidence gaps and a lack of long-term safety data.

Cite This Study

Han et al. (2026) studied this question.

synapsesocial.com/papers/6a85638803308d306e2d6bef https://doi.org/10.1159/000553430

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Implication

Narrative review reveals mitochondrial signaling cascades drive systemic aging across multiple organ axes, highlighting therapeutic targets for extending healthspan.

Mitochondrial Dysfunction as a Central Hub of Aging: From Molecular Cascades to Inter-Organ Communication Networks

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Implication

Key Points

Cite This Study

Mitochondrial Dysfunction as a Central Hub of Aging: From Molecular Cascades to Inter-Organ Communication Networks

Discussion

Member takes

Implication

Key Points

Cite This Study

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