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This review aims to synthesize mechanistic insights into mitochondrial dysfunction and analyze therapeutic challenges in aging-related diseases.

June 7, 2026MedCommOpen Access

Targeting Mitochondria in Aging‐Related Diseases: Therapeutic Potential and Obstacles

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This review aims to synthesize mechanistic insights into mitochondrial dysfunction and analyze therapeutic challenges in aging-related diseases.
Systematic summarization of pathways related to mitochondrial dysfunction in aging.
Analysis of mitochondrial targeted treatment strategies, including metabolism regulation and emerging technologies.
Emphasis on obstacles affecting clinical translation, such as tissue-specific mitochondrial heterogeneity.
Outlined pathways leading to mitochondrial dysfunction and its role in aging-related diseases.
Highlighted therapeutic strategies such as mitochondrial transplantation and DNA base editing.
Identified key obstacles to clinical application, focusing on mitochondrial heterogeneity.

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Review analyzes mitochondrial dysfunction and therapeutic strategies in aging-related diseases, highlighting obstacles.

Xiang et al. (2026) studied this question.

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