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This review discusses how the regulation of platelet adhesion receptor levels impacts platelet function, thrombus formation, and platelet survival.
This review highlights the role of metalloproteolytic receptor shedding in regulating platelet adhesion receptors, impacting platelet function, aging, and survival.
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May inform antiplatelet target development; leaves open clinical translation of receptor shedding modulation.
Whilst significant effort has been focused on development of tools and approaches to clinically modulate activation processes that consume platelets, the platelet receptors that initiate activation processes remain untargeted. The modulation of receptor levels is also linked to underlying platelet aging processes which influence normal platelet lifespan and also the functionality and survival of stored platelets that are used in transfusion. In this review, we will focus on platelet adhesion receptors initiating thrombus formation, and discuss how regulation of levels of these receptors impact platelet function and platelet survival.
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Andrews et al. (2016) conducted a review in Platelet function and survival. Platelet adhesion receptors was evaluated. This review discusses how the regulation of platelet adhesion receptor levels impacts platelet function, thrombus formation, and platelet survival.
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