Key result
Platelet receptor shedding mechanisms, including sheddase activity and regulatory factors like shear stress, provide potential targets for controlling platelet reactivity and function.
Design
Review
Authors
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Shedding pathways merit consideration in platelet disorders; leaves open targeted modulation for thrombosis pending clinical trials.
Understanding platelet receptor shedding mechanisms may help identify novel platelet-specific biomarkers and therapeutic targets for controlling platelet reactivity in atherothrombotic diseases.
Andrews et al. (2016) conducted a review in Platelet receptor shedding. Platelet receptor shedding mechanisms, including sheddase activity and regulatory factors like shear stress, provide potential targets for controlling platelet reactivity and function.
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