Key result
In a canine model, LV dysfunction without dilatation failed to produce important MR, whereas changes in the 3D geometry of mitral valve attachments strongly predicted MR volume (R2=0.82-0.85).
Why the study?
Does geometric distortion of the mitral apparatus due to LV dilatation cause functional mitral regurgitation rather than global LV dysfunction alone?
Population
6 dogs with a model of global left ventricular (LV) dysfunction
Comparison
Global LV dysfunction induced by esmolol and… vs Global LV dysfunction with LV expansion limited…
Design
Preclinical
Authors
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Geometric distortion over global dysfunction refines functional MR mechanisms in canines; leaves open human translation.
Does geometric distortion of the mitral apparatus due to LV dilatation cause functional mitral regurgitation rather than global LV dysfunction alone?
Effect estimate: R2=0.82 to 0.85
p-value: p=2x10(-7) to 6x10(-8)
Functional mitral regurgitation is primarily driven by geometric distortion of the mitral valve attachments due to LV dilatation rather than global LV dysfunction alone.
Otsuji et al. (1997) studied Functional mitral regurgitation (n=6). LV dilatation (pericardium opened) vs. Limited LV dilatation (pericardial restraint) was evaluated on Mitral regurgitant volume and orifice area (R2=0.82 to 0.85, p=2x10(-7) to 6x10(-8)). In a canine model, LV dysfunction without dilatation failed to produce important MR, whereas changes in the 3D geometry of mitral valve attachments strongly predicted MR volume (R2=0.82-0.85).
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