Why the study?
Does altering the balance of tethering versus coapting forces affect functional mitral regurgitation in an in vitro porcine valve model?
Population
Excised porcine valves in an in vitro model
Comparison
Independent variation of papillary muscle… vs Different geometric configurations and pressures…
Design
Preclinical
Authors
Loading...
No immediate clinical implications; extends in vitro confirmation of tethering-coapting imbalance but leaves human translation open.
Does altering the balance of tethering versus coapting forces affect functional mitral regurgitation in an in vitro porcine valve model?
In vitro modeling confirms that functional mitral regurgitation results from an altered balance of tethering versus coapting forces, with increased transmitral pressure acting to close the leaflets and decrease regurgitant orifice area.
He et al. (1997) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: