Key result
Altered TNF and TGF-β1 correlate only weakly with LV function in chronic Chagas cardiomyopathy.
Why the study?
Do TGF-β1 and TNF serum levels correlate with left ventricular function in patients with chronic Chagas disease?
Cross-Sectional (n=193)
Single-blind
No
Do TGF-β1 and TNF serum levels correlate with left ventricular function in patients with chronic Chagas disease?
TGF-β1 and TNF serum levels are altered in the cardiac form of Chagas disease but show only weak correlations with cardiac function, limiting their utility as surrogate markers of disease progression in standard clinical practice.
Answers are grounded in this paper and cite their sources.
Altered TNF and TGF-β1 levels show limited surrogate value for LV function in Chagas cardiomyopathy; leaves open their role in prospective monitoring.
BACKGROUND: Transforming growth factor β1 (TGF-β1) and tumour necrosis factor (TNF) have been implicated in Chagas disease pathophysiology and may correlate with left ventricular (LV) function. OBJECTIVES: We determined whether TGF-β1 and TNF serum levels correlate with LV systolic and diastolic functions and brain natriuretic peptide (BNP) serum levels in chronic Chagas disease. METHODS: This cross-sectional study included 152 patients with Chagas disease (43% men; 57 ± 12 years old), classified as 53 patients with indeterminate form and 99 patients with cardiac form (stage A: 24, stage B: 25, stage C: 44, stage D: 6). TGF-β1, TNF, and BNP were determined by enzyme-linked immunosorbent assay ELISA. Echocardiogram was used to determine left atrial and LV diameters, as well as LV ejection fraction and diastolic function. FINDINGS: TGF-b1 serum levels were lower in stages B, C, and D, while TNF serum levels were higher in stages C and D of the cardiac form. TGF-β1 presented a weak correlation with LV diastolic function and LV ejection fraction. TNF presented a weak correlation with left atrial and LV diameters and LV ejection fraction. CONCLUSIONS: TNF is increased, while TGF-β1 is decreased in the cardiac form of chronic Chagas disease. TNF and TGF-β1 serum levels present a weak correlation with LV systolic and diastolic function in Chagas disease patients.
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Curvo et al. (2018) conducted a cross-sectional in Chagas disease (n=193). TGF-β1 and TNF serum levels vs. Non-infected controls and patients with indeterminate Chagas disease was evaluated on Correlation of TGF-β1 and TNF serum levels with left ventricular systolic and diastolic functions and BNP. TNF serum levels were increased while TGF-β1 levels were decreased in the cardiac form of chronic Chagas disease, and both presented only weak correlations with left ventricular systolic and diastolic function.
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