Elevated TNF-alpha and CCL2 levels correlate with heart dysfunction in Chagasic cardiomyopathy, suggesting TNF-alpha could be a useful biomarker for identifying patients at risk for heart failure.
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TNF-alpha merits prospective validation as a heart failure biomarker in Chagas; cross-sectional data leave its clinical utility open.
Talvani et al. (2004) studied this question.
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