February 1, 2001Echocardiography
Doppler Tissue Imaging to Evaluate Early Myocardium Damage in Patients with Undetermined Form of Chagas' Disease and Normal Echocardiogram
Key result
Doppler tissue imaging identified early contractile abnormalities, notably a significantly higher isovolumic contraction time along the septal wall, in patients with undetermined Chagas' disease.
Why the study?
Does Doppler tissue imaging detect early myocardial damage in patients with undetermined form of Chagas' disease and normal echocardiogram compared to normal controls?
Population
40 patients, including 21 with an undetermined form of Chagas' disease and 19 normal control individuals.
Comparison
Doppler tissue imaging to evaluate longitudinal… vs Normal control individuals evaluated with DTI
Design
Case-control
Authors
Discussion
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Implication
Suggests tissue Doppler may detect subclinical Chagas involvement; hypothesis-generating and should not yet change practice.
Key Points
- To determine whether Doppler tissue imaging can identify early longitudinal contractile dysfunction in patients with the undetermined form of Chagas disease who have normal standard echocardiographic findings.
- Evaluated 40 participants, including 21 patients with undetermined Chagas disease (normal electrocardiogram, chest radiography, and standard echocardiography) and 19 healthy control subjects.
- Utilized Doppler tissue imaging to examine longitudinal contractility across myocardial segments, quantifying systolic velocities, diastolic velocities, and isovolumic contraction time (IVCT).
- Systolic function velocity rates were similar across groups, but isovolumic contraction time along the septal wall was significantly higher in the Chagas disease cohort.
- Doppler tissue imaging detected early localized contractility abnormalities specifically in the interventricular septum of Chagas patients with otherwise normal echocardiograms.
Study Design
Type
Case-Control (n=40)
Structured PICO
Does Doppler tissue imaging detect early myocardial damage in patients with undetermined form of Chagas' disease and normal echocardiogram compared to normal controls?
P
Population
40 individuals, including 21 patients with an undetermined form of Chagas' disease and normal standard cardiac evaluations, and 19 normal controls.
E
Exposure
Doppler tissue imaging (DTI) to evaluate longitudinal contractility (systolic and diastolic velocities and isovolumic contraction time)
C
Comparator
Normal control individuals evaluated with DTI
O
Outcome
Longitudinal contractility abnormalities (systolic and diastolic velocities and isovolumic contraction time)surrogate
Doppler tissue imaging can detect early contractile abnormalities, specifically prolonged isovolumic contraction time in the interventricular septum, in asymptomatic Chagas' disease patients with otherwise normal echocardiograms.
Cite This Study
Barros et al. (2001) conducted a case-control in Undetermined form of Chagas' disease (n=40). Doppler tissue imaging (DTI) vs. Normal control individuals was evaluated on Longitudinal contractility including systolic and diastolic velocities and isovolumic contraction time (IVCT). Doppler tissue imaging identified early contractile abnormalities, notably a significantly higher isovolumic contraction time along the septal wall, in patients with undetermined Chagas' disease.