Key result
Tissue Doppler imaging demonstrated early right and left ventricular systolic and diastolic myocardial damage in patients with indeterminate Chagas disease compared to healthy controls.
Why the study?
Chagas disease is widespread in Latin America with cardiac involvement being the primary cause of death, but whether tissue Doppler imaging can detect early ventricular dysfunction in the indeterminate form remained to be determined.
Does tissue Doppler imaging (TDI) detect early myocardial dysfunction in patients with the indeterminate form of Chagas disease compared to healthy controls?
Case-Control (n=266)
Does tissue Doppler imaging (TDI) detect early myocardial dysfunction in patients with the indeterminate form of Chagas disease compared to healthy controls?
Tissue Doppler imaging can detect early right and left ventricular systolic and diastolic dysfunction in patients with the indeterminate form of Chagas disease, potentially identifying those at risk for progression to heart failure.
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Supports TDI for detecting subclinical Chagas cardiomyopathy; leaves open prognostic validation before clinical adoption.
Cianciulli et al. (2020) conducted a case-control in Indeterminate form of Chagas disease (n=266). Indeterminate form of Chagas disease vs. Age-matched healthy individuals was evaluated on Tissue Doppler imaging (TDI) parameters for left and right ventricular function. Tissue Doppler imaging demonstrated early right and left ventricular systolic and diastolic myocardial damage in patients with indeterminate Chagas disease compared to healthy controls.
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