Key result
Patients in the indeterminate phase of Chagas' disease had early left ventricular diastolic dysfunction, shown by a longer deceleration time of early diastolic filling (167.9 vs 138.7 msec, p=0.001).
Why the study?
Does transmitral Doppler flow detect early abnormalities of diastolic left ventricular function in asymptomatic patients with indeterminate phase Chagas' disease?
Cross-Sectional (n=81)
Does transmitral Doppler flow detect early abnormalities of diastolic left ventricular function in asymptomatic patients with indeterminate phase Chagas' disease?
Absolute Event Rate: 167.9% vs 138.7%
p-value: p=0.001
Transmitral Doppler flow can detect early left ventricular diastolic dysfunction in asymptomatic patients with the indeterminate phase of Chagas' disease who have normal standard echocardiograms.
Authors
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May identify subclinical LV diastolic dysfunction in indeterminate Chagas; hypothesis-generating and requires prospective validation.
Cianciulli et al. (2006) conducted a cross-sectional in Chagas' disease (n=81). Chagas' disease (indeterminate phase) vs. Healthy subjects was evaluated on Deceleration time of early diastolic filling (msec) (p=0.001). Patients in the indeterminate phase of Chagas' disease had early left ventricular diastolic dysfunction, shown by a longer deceleration time of early diastolic filling (167.9 vs 138.7 msec, p=0.001).
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