Key result
Response to cardiac resynchronization therapy was associated with decreased TGF-β1, IL-6, and TNF-α, while higher pre-implant TGF-β1 independently predicted mortality at 2 years.
Why the study?
Does cardiac resynchronization therapy alter apoptotic and inflammatory cytokine levels, and do pre-implant levels predict mortality in heart failure patients?
Population
81 heart failure patients who are candidates for cardiac resynchronization therapy (CRT)
Design
Cohort
Follow-up
6 months for cytokine changes; 2 years for mortality
Authors
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May support TGF-β1 for risk stratification in CRT candidates; hypothesis-generating for cytokine modulation trials.
Cohort (n=81)
Does cardiac resynchronization therapy alter apoptotic and inflammatory cytokine levels, and do pre-implant levels predict mortality in heart failure patients?
Response to CRT is associated with a decrease in inflammatory cytokines, and elevated pre-implant TGF-β1 levels independently predict poor long-term prognosis.
Osmančík et al. (2013) conducted a cohort in Heart failure (n=81). Cardiac resynchronization therapy (CRT) vs. Nonresponders was evaluated on Changes in cytokine concentrations at 6 months and mortality at 2 years. Response to cardiac resynchronization therapy was associated with decreased TGF-β1, IL-6, and TNF-α, while higher pre-implant TGF-β1 independently predicted mortality at 2 years.
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