Key result
Preoperative systemic plasma levels of Big ET-1 were significantly higher in patients with colorectal cancer than in controls (median 1.0 vs 0.2 fmol/ml; P=0.0001).
Why the study?
Are plasma Big Endothelin 1 levels elevated in patients with colorectal cancer compared to controls?
Population
37 patients with colorectal cancer and 20 age- and sex-matched controls
Comparison
Measurement of plasma Big Endothelin (ET) 1 levels vs Age- and sex-matched controls
Design
Case-control
Authors
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Supports Big ET-1 investigation as colorectal cancer biomarker; leaves open clinical utility pending prospective validation.
Case-Control (n=57)
Are plasma Big Endothelin 1 levels elevated in patients with colorectal cancer compared to controls?
Absolute Event Rate: 1% vs 0.2%
p-value: p=0.0001
Plasma Big Endothelin 1 levels are significantly elevated in colorectal cancer patients, particularly those with liver metastases, suggesting a potential role as a disease marker.
Simpson et al. (2000) conducted a case-control in Colorectal cancer (n=57). Colorectal cancer vs. Age- and sex-matched controls was evaluated on Preoperative systemic plasma levels of Big ET-1 (fmol/ml) (p=0.0001). Preoperative systemic plasma levels of Big ET-1 were significantly higher in patients with colorectal cancer than in controls (median 1.0 vs 0.2 fmol/ml; P=0.0001).
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