Key result
Phylogenetic analysis of four FMDV serotype O isolates from cattle in Bangladesh revealed two clustered within the emerging sublineage Ind2001BD1 and one within lineage PanAsia.
Why the study?
Foot-and-mouth disease is endemic in cloven-hoofed animals in Bangladesh with multiple annual outbreaks, prompting investigation into the molecular characterization of the VP1 coding region of FMDV serotype O.
Observational (n=4)
Multiple lineages of FMDV serotype O are circulating among cattle in Bangladesh, complicating control programs.
Multiple FMDV O lineages in Bangladeshi cattle may hinder control; leaves open needs for updated surveillance and vaccines.
Background: Foot-and-mouth disease (FMD) is an endemic disease of cloven-hoofed animals in Bangladesh and multiple outbreaks occur every year because of the FMD virus (FMDV). Aim: The aim of the present investigation was to determine the molecular characterization of the VP1 coding region of FMDV serotype O outbreak in cattle. Methods: A total of four tongue epithelial specimens were collected from clinically FMD-positive cattle during June 2018 in Manikgonj district of Bangladesh. Results: All four isolates were recorded positive for FMDV serotype O. The phylogenetic analysis showed that two isolates were clustered within an emerging novel sublineage Ind2001BD1 under lineage Ind2001 of FMDV serotype O, which was identified during 2012-2016 in Bangladesh. One isolate was clustered within the lineage PanAsia of FMDV serotype O and was closely related to an isolate identified in Nepal in 2009. The phylogenetic reconstruction revealed that all the four isolates belong to the Middle East-South Asia topotype. Conclusion: Therefore, multiple lineages of the FMDV serotype O are circulating among the cattle in the outbreak area, which make it more complex for the FMD control program in Bangladesh. A comprehensive study on the genetic characteristics of FMDV across the country is required for effective FMD prevention and control strategy.
No takes yet. Share an insight, caveat, or question.
Ali et al. (2020) conducted an observational in Foot-and-mouth disease (FMD) (n=4). FMDV serotype O infection was evaluated on Molecular characterization of the VP1 coding region. Phylogenetic analysis of four FMDV serotype O isolates from cattle in Bangladesh revealed two clustered within the emerging sublineage Ind2001BD1 and one within lineage PanAsia.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: