Key result
Phylogenetic analysis of six field isolates confirmed the emergence of the FMDV serotype O PanAsia-02 sub-lineage under the Middle East-South Asian topotype in Bangladesh.
Why the study?
This study was conducted for the molecular characterization and serotype identification of circulating foot-and-mouth disease virus in Bangladesh.
The study confirms the presence of the FMDV serotype O PanAsia-02 sub-lineage in Bangladesh, likely due to cross-border animal movement.
May warrant enhanced FMD surveillance in Bangladesh; leaves open needs for vaccine updates and regional spread studies.
OBJECTIVE: This research work was conducted for the molecular characterization of the circulating foot-and-mouth disease (FMD) virus in Bangladesh and revealed out their serotype. MATERIALS AND METHODS: gene of six field isolates of FMD virus (FMDV) serotypes (two serotypes O, two serotypes A, and two serotypes Asia 1) was subjected for sequencing and phylogenetic analysis. Neighbor-joining trees were constructed by using the Molecular Evolutionary Genetics Analysis 6, having the field nucleotide sequences of FMDV and related sequences available in the GenBank. RESULTS: genes of serotypes O, A, and Asia-1 of the isolates revealed that overall isolates were 91%-100% similar to the isolates reported from Bangladesh and other neighboring countries. Among the isolates reported from Bangladesh, serotype O had 98%-100% identity, serotype A had 91%-100% identity, and serotype Asia-1 had 94%-100% identity. A phylogenetic analysis revealed that the FMDV serotype O PanAsia-02 sub-lineage was confirmed in Bangladesh under the Middle East-South Asian (ME-SA) topotype. On the other hand, we identified genotype VII (18) of Asia topotype (serotype A) and lineage C (serotype Asia-1). CONCLUSION: The FMDV serotype O PanAsia-02 sub-lineage was confirmed in Bangladesh under the ME-SA topotype for the first time. The extensive cross-border animal movement from neighboring countries may act as the source of diversified FMDV serotypes in Bangladesh.
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Hossen et al. (2020) studied Foot-and-mouth disease virus (FMDV) (n=6). Molecular characterization and phylogenetic analysis was evaluated on Genetic similarity and phylogenetic lineage. Phylogenetic analysis of six field isolates confirmed the emergence of the FMDV serotype O PanAsia-02 sub-lineage under the Middle East-South Asian topotype in Bangladesh.
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