Excellent T-cell reconstitution and survival depend on low ATG exposure after pediatric cord blood transplantation

Rick Admiraal; Caroline A. Lindemans; Charlotte van Kesteren; Marc Bierings; A. Birgitta Versluijs; Stefan Nierkens; Jaap Jan Boelens

doi:10.1182/blood-2016-06-721936

October 4, 2016BloodOpen Access

Excellent T-cell reconstitution and survival depend on low ATG exposure after pediatric cord blood transplantation

View Full Paper

Ask AI

Bookmark

Share

Key Points

The aim is to determine how reduced exposure to ATG affects T-cell reconstitution and survival after pediatric cord blood transplantation (CBT).
Evaluated individualized dosing of ATG during CBT procedures.
Monitored T-cell reconstitution post-transplantation.
Compared outcomes with and without ATG exposure in pediatric patients.
Enhanced T-cell reconstitution observed with low ATG exposure.
Significant improvement in survival rates post-CBT with reduced ATG.
Optimal ATG dosing strategies potentially lead to better transplant outcomes.

Ask about this paper

Answers are grounded in this paper and cite their sources.

Abstract

IR after CBT, which can be achieved by reducing the exposure to ATG after CBT. Individualized dosing of ATG to reach optimal exposure or, in selected patients, omission of ATG may contribute to improved outcomes in pediatric CBT.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Admiraal et al. (2016) studied this question.

synapsesocial.com/papers/6a216af436bad5b948f1abe1 https://doi.org/10.1182/blood-2016-06-721936

View Full Paper

Ask AI

Bookmark

Share

Excellent T-cell reconstitution and survival depend on low ATG exposure after pediatric cord blood transplantation

Key Points

Ask about this paper

Abstract

Discussion

Cite This Study

Excellent T-cell reconstitution and survival depend on low ATG exposure after pediatric cord blood transplantation

Key Points

Ask about this paper

Abstract

Discussion

Cite This Study

Keep reading

Keep reading