Key result
Single-molecule mechanics studies show reasonable correspondence with muscle mechanics for cross-bridge power-stroke distance, stiffness, and force, but conflict in areas like elasticity.
Population
Actomyosin single-molecule mechanics and contracting muscle models
Design
Review
Authors
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May refine cardiac cross-bridge models; leaves open elasticity conflicts for targeted experiments.
Single-molecule mechanics data generally predict the mechanics of contracting muscle well, though some specific mechanisms remain conflicting.
Månsson et al. (2018) conducted a review in Muscle mechanics. Single-molecule mechanics studies vs. Muscle mechanics studies was evaluated on Correspondence in estimates of cross-bridge mechanics. Single-molecule mechanics studies show reasonable correspondence with muscle mechanics for cross-bridge power-stroke distance, stiffness, and force, but conflict in areas like elasticity.
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