Key result
Following the introduction of rotavirus vaccines, the annual prevalence of rotavirus gastroenteritis decreased significantly, whereas the prevalence of associated benign convulsions did not.
Why the study?
To assess the impact of rotavirus vaccines introduced in South Korea in 2007 on changes in the prevalence of factors associated with rotavirus gastroenteritis and rotavirus-associated benign convulsions with mild gastroenteritis.
Does the introduction of rotavirus vaccines impact the prevalence of rotavirus gastroenteritis and rotavirus-associated benign convulsions with mild gastroenteritis in children under 3 years?
Observational (n=223,718)
Yes
Does the introduction of rotavirus vaccines impact the prevalence of rotavirus gastroenteritis and rotavirus-associated benign convulsions with mild gastroenteritis in children under 3 years?
The introduction of rotavirus vaccines in South Korea significantly decreased the prevalence of rotavirus gastroenteritis, but the decrease in rotavirus-associated benign convulsions was not as pronounced.
Rotavirus vaccines were associated with lower gastroenteritis prevalence but not convulsions; hypothesis-generating and requires prospective confirmation before practice change.
Using nationwide data from the Health Insurance Review and Assessment service, we assessed the impact of rotavirus vaccines, introduced in South Korea, in 2007, on changes in the prevalence of factors (age, sex, and geographic location) associated with rotavirus gastroenteritis (RVGE) and rotavirus-associated benign convulsions with mild gastroenteritis (RaCwG). We analyzed health records of children younger than 3 years who visited clinical facilities and were diagnosed with RVGE or RaCwG between 2007 and 2019. The annual mid-year population (MYP) was obtained from the Korean Statistical Information Service. The annual prevalence of RVGE, RaCwG and associated factors were statistically analyzed. Overall, 219,686, and 4032, children were confirmed to have RVGE and RaCwG, respectively. Although the annual prevalence of RVGE decreased significantly, that of RaCwG did not. The annual ratio of RaCwG to RVGE was significantly high. Compared to the prevalence of RVGE, the prevalence of RaCwG was significantly lower in rural areas. The age of RaCwG patients was significantly lower than that of the MYP and that of RVGE patients. The decrease in the number of RaCwG patients after rotavirus vaccination was not as pronounced as the decrease in the number of RVGE patients.
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Kim et al. (2020) conducted an observational in Rotavirus gastroenteritis (RVGE) and rotavirus-associated benign convulsions with mild gastroenteritis (RaCwG) (n=223,718). Rotavirus vaccines was evaluated on Annual prevalence of RVGE and RaCwG. Following the introduction of rotavirus vaccines, the annual prevalence of rotavirus gastroenteritis decreased significantly, whereas the prevalence of associated benign convulsions did not.
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