Key result
Progressive cardiovascular involvement was more frequent among children diagnosed with Marfan's syndrome before 10 years of age compared with those diagnosed later (60% vs 12.5%).
Observational (n=25)
Absolute Event Rate: 60% vs 12.5%
Cardiovascular involvement is a common feature of childhood Marfan's syndrome, with sporadic cases and diagnosis before age 10 representing a particularly high-risk group for progressive disease and mortality.
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Earlier diagnosis may identify higher-risk children for closer monitoring; hypothesis-generating and requires prospective confirmation.
illTal Geva (1987) conducted an observational in Marfan's syndrome (n=25). Age at diagnosis <10 years vs. Age at diagnosis ≥10 years was evaluated on Progressive cardiovascular involvement. Progressive cardiovascular involvement was more frequent among children diagnosed with Marfan's syndrome before 10 years of age compared with those diagnosed later (60% vs 12.5%).
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