Key result
CSI-positive status linked to ~28 percentage points higher very early recurrence after AF ablation.
Why the study?
Does complex signal identification (CSI) positivity predict very early recurrence and slower left atrial conduction velocity in atrial fibrillation patients undergoing radiofrequency ablation without low-voltage areas?
Observational (n=43)
No
Does complex signal identification (CSI) positivity predict very early recurrence and slower left atrial conduction velocity in atrial fibrillation patients undergoing radiofrequency ablation without low-voltage areas?
Absolute Event Rate: 33% vs 5%
p-value: p=0.02
Complex signal identification (CSI) can identify early left atrial electrical remodeling within normal voltage regions, and CSI positivity is significantly associated with slower left atrial conduction and very early recurrence after atrial fibrillation ablation.
CSI positivity was associated with very early AF recurrence; hypothesis-generating for subtle remodeling detection and needs prospective validation.
CSI burden LA conduction velocity CSI-positive Very early AF recurrence (within blanking period) Post-procedural LA mapping & Complex Signal Identification (CSI) definition High-density LA mapping: OCTARAY CSI = fractionation score 7.5 within normal bipolar voltage CSI points CSI-positive group: patients with 1 CSI-positive point Population Atrial fibrillation patients undergoing radiofrequency ablation without low-voltage areas in left atrium (LA) Low-voltage area: bipolar voltage < 0.5 mV LA conduction velocity CSI burden Recurrence rate CSI-positive group CSI-negative group 33% 5% P = 0.02 = -0.440P = 0.003 Fractionated electrogram Take home message: CSI identifies early atrial remodeling within regions of normal voltage.
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Nodera et al. (2026) conducted an observational in Atrial Fibrillation (n=43). Complex signal identification (CSI) positivity vs. CSI-negative status was evaluated on Very early recurrence of atrial fibrillation or atrial tachycardia (within 3-month blanking period) (p=0.02). Patients with CSI-positive regions had a significantly higher rate of very early recurrence after atrial fibrillation ablation compared to CSI-negative patients (33% vs 5%, p=0.02).
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