Key result
Systemic hypertension promotes cardiovascular disease via arterial stiffness, left atrial overload, and increased AF risk.
This paper reviews the pathophysiological connections between systemic arterial hypertension, arterial stiffness, atrial cardiomyopathy, and the development of atrial arrhythmias.
Hypertension control may curb AF via stiffness pathways; leaves open targeted trials on atrial cardiomyopathy.
Systemic arterial hypertension (SAH) is the primary risk factor for cardiovascular disease, promoting activation of the renin-angiotensin-aldosterone system (RAAS), endothelial dysfunction, arterial stiffness, fibrosis, and myocardial hypertrophy. Prospective studies show that the consequences include left ventricular hypertrophy (LVH), left atrial (LA) overload, and a higher risk of atrial fibrillation (AF). In the classic Framingham study, hypertension was an independent predictor of AF and, on its own, accounted for more cases of this arrhythmia than any other risk factor. The recognition [...]
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Gismondi et al. (2024) conducted a review in Systemic arterial hypertension and atrial arrhythmias. Systemic arterial hypertension was evaluated. Systemic arterial hypertension is a primary risk factor for cardiovascular disease, promoting arterial stiffness, left atrial overload, and a higher risk of atrial fibrillation.
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