Population
KCNQ1-KCNE1 complexes
Design
Preclinical
Authors
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Does not alter LQTS management; hypothesis-generating for KCNE1-KCNQ1 interactions pending functional validation.
The identification of an alpha-helical secondary structure in the KCNE1 C-terminal domain provides a structural scaffold for mapping interactions with KCNQ1, relevant to understanding the mechanisms of long QT syndrome.
Rocheleau et al. (2006) studied this question.
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