June 1, 1996Nephrology Dialysis Transplantation

Atrial natriuretic peptide, sodium retention, and proteinuria in nephrotic syndrome

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Why the study?

Does ANP infusion increase natriuresis and affect proteinuria in patients with nephrotic syndrome?

Structured PICO

Does ANP infusion increase natriuresis and affect proteinuria in patients with nephrotic syndrome?

Population

31 patients (aged 35+/-11 years) with compensated treated nephrotic syndrome due to primary glomerulonephritis (serum creatinine <=1.4 mg/dl, off diuretics for >=24h) and 10 healthy controls.

Intervention

Alpha atrial natriuretic peptide (ANP) infusion (0.005 microg/kg*min)

Comparator

Placebo

Outcome

Plasma ANP concentration, renal haemodynamics, natriuresis, and proteinuria (total protein, albumin, IgG excretion)surrogate

ANP infusion increases natriuresis but also enhances urinary protein excretion in patients with nephrotic syndrome, likely due to increased glomerular permeability.

Discussion

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Implication

ANP infusion boosts natriuresis yet worsens proteinuria in nephrotic syndrome; extends glomerular permeability data but cautions against clinical use.

Cite This Study

Plüm et al. (1996) studied this question.

synapsesocial.com/papers/6a217be136bad5b948f1bb63 https://doi.org/10.1093/ndt/11.6.1034

Topics

Sermorelin

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Implication

ANP infusion boosts natriuresis yet worsens proteinuria in nephrotic syndrome; extends glomerular permeability data but cautions against clinical use.

Atrial natriuretic peptide, sodium retention, and proteinuria in nephrotic syndrome

Structured PICO

Discussion

Implication

Cite This Study

Topics

Atrial natriuretic peptide, sodium retention, and proteinuria in nephrotic syndrome

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider