Why the study?
Does synthetic α-hANP infusion increase urinary protein excretion in patients with primary glomerular diseases compared to healthy subjects?
Does synthetic α-hANP infusion increase urinary protein excretion in patients with primary glomerular diseases compared to healthy subjects?
Infusion of α-hANP acutely increases urinary protein excretion in patients with primary glomerular diseases, suggesting it increases transglomerular permeability in damaged glomeruli.
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α-hANP infusion may increase proteinuria in glomerulonephritis; hypothesis-generating for glomerular permeability effects, requiring prospective validation before any clinical consideration.
Ishii et al. (1989) studied this question.
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