T cells in chronic lymphocytic leukemia display dysregulated expression of immune checkpoints and activation markers

December 7, 2016HaematologicaOpen Access

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Key Points

This study aims to analyze T-cell dysregulation regarding immune checkpoints and activation markers in chronic lymphocytic leukemia patients.
Analyzed T-cell phenotype in chronic lymphocytic leukemia patients (n=80) focusing on immune checkpoints and activation markers.
Compared findings with healthy controls.
Assessed absolute numbers of CD3+, CD4+, and CD8+ cells, including those expressing PD-1 and CTLA-4.
Patients exhibited higher absolute numbers of CD3+ T cells, especially CD8+ cells in previously treated cohorts.
Progressive patients had significantly higher PD-1 expressing CD4+ (P=0.0003) and CD8+ (P=0.001) cells compared to healthy controls.
Significant increases in activated (CD69+) and proliferating (Ki67+) T cells were observed, particularly in patients with active disease.

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Analysis reveals T-cell dysfunction in chronic lymphocytic leukemia, indicating potential therapeutic targets.

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Palma et al. (2016) studied this question.

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