Key result
High-capacity runner rats demonstrated significantly greater isolated cardiac output compared to low-capacity runners (49.9 vs 33.5 ml/min/g, P<0.001), but no difference in recovery from ischemia.
Population
Generation 3 rat genetic models of intrinsic low-capacity runners and high-capacity runners
Comparison
High-capacity running (HCR) genetic phenotype vs Low-capacity running (LCR) genetic phenotype
Design
Preclinical
Authors
Loading...
Intrinsic exercise capacity links to higher baseline cardiac output in rats without ischemia protection; leaves open human translation.
Effect estimate: 49% difference
Absolute Event Rate: 49.9% vs 33.5%
p-value: p=<0.001
Genetically determined intrinsic capacity for exercise is associated with increased baseline cardiac performance but does not confer resistance to global low-flow cardiac ischemia.
Hussain et al. (2001) studied Intrinsic running capacity. High-capacity running (HCR) genetic model vs. Low-capacity running (LCR) genetic model was evaluated on Isolated cardiac performance (cardiac output at constant preload and afterload) (49% difference, p=<0.001). High-capacity runner rats demonstrated significantly greater isolated cardiac output compared to low-capacity runners (49.9 vs 33.5 ml/min/g, P<0.001), but no difference in recovery from ischemia.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: