Key result
Global longitudinal strain measured by 2D speckle tracking echocardiography accurately detected subtle left ventricular systolic dysfunction in moderate asymptomatic chronic aortic regurgitation with an AUC of 0.981.
Why the study?
Early detection of subclinical LV systolic dysfunction could influence prognosis and help select asymptomatic chronic aortic regurgitation patients for better management.
Does Two Dimensional Speckle Tracking Echocardiography accurately detect early LV systolic dysfunction in asymptomatic patients with chronic aortic regurgitation?
Cross-Sectional (n=111)
Yes
Does Two Dimensional Speckle Tracking Echocardiography accurately detect early LV systolic dysfunction in asymptomatic patients with chronic aortic regurgitation?
Effect estimate: AUC 0.981
p-value: p=<0.0001
Global longitudinal strain by 2D speckle tracking echocardiography is a highly sensitive and specific screening tool for early detection of subclinical LV systolic dysfunction in asymptomatic chronic aortic regurgitation.
GLS by 2D STE may aid early detection in asymptomatic moderate AR; hypothesis-generating and requires prospective validation before practice change.
Background: Early detection of subclinical left ventricular (LV) systolic dysfunction is crucial and could influence patients' prognosis by aiding the clinician to candidate patients for better management. Objective: To detect early LV systolic dysfunction in asymptomatic patient with chronic aortic regurgitation by two dimensional speckle tracking echocardiography. Methods: Sixty one asymptomatic patients with chronic aortic regurgitation, with no ischemic heart diseases (by coronary angiography) or conductive heart diseases, no diabetes mellitus, no hypertension, and no other valvular heart diseases (group 1) and fifty age and sex-matched healthy subjects (group 2) were enrolled into the study. Group (1) was further classified into 3 sub-groups according to 4 chosen parameters from the published guidelines of American Society of Echocardiography (ASE) into: Mild AR, Moderate AR, and Severe AR. All patients and controls underwent echocardiographic examination including conventional echocardiography, tissue Doppler study and Two Dimensional (2-D) Speckle Tracking Echocardiography. Results: GLS showed the highest sensitivity and specificity in detection of subtle LV systolic dysfunction in moderate AR. In moderate AR,a cut off value of > (-19.62) has sensitivity and specificity of 91.3% and 95.5% respectively, with Positive Predictive Value (PPV) and Negative Predictive Value ( NPV ) of 87.5% and 96.9% respectively, Area under curve (AUC) of 0.981. In all types of AR, GLS had higher NPV than PPV which makes it a powerful screening tool for early detection of subtle LV systolic dysfunction. Conclusion: Global Longitudinal strain measured by 2-D speckle tracking echocardiography is an excellent tool for early detection of subtle LV systolic dysfunction in asymptomatic patients with chronic AR
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Al-Jawahiri et al. (2019) conducted a cross-sectional in Asymptomatic Chronic Aortic Regurgitation (n=111). Global Longitudinal Strain (GLS) by 2D speckle tracking echocardiography vs. Healthy controls and conventional echocardiography (EF) was evaluated on Detection of left ventricular systolic dysfunction in moderate aortic regurgitation (AUC 0.981, p=<0.0001). Global longitudinal strain measured by 2D speckle tracking echocardiography accurately detected subtle left ventricular systolic dysfunction in moderate asymptomatic chronic aortic regurgitation with an AUC of 0.981.
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