Key result
Type D personality was associated with increased inflammation, which mediated its relationship with coronary plaque rupture vulnerability (effect size 0.16; 95% CI 0.043-0.365; P=0.024).
Why the study?
The underlying mechanisms connecting type D personality with coronary plaque vulnerability in patients with coronary artery disease remained indeterminate.
Does inflammation mediate the association between Type D personality and coronary plaque vulnerability in patients with CAD?
Population
347 patients with CAD and culprit coronary plaques
Comparison
Type D personality vs non-type D personality
Design
Cross-sectional optical coherence tomography study
Authors
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May support inflammatory mediation of Type D effects on plaque vulnerability in CAD; hypothesis-generating, needs prospective confirmation.
Cross-Sectional (n=347)
Does inflammation mediate the association between Type D personality and coronary plaque vulnerability in patients with CAD?
Effect estimate: effect size 0.16 (95% CI 0.043-0.365)
p-value: p=.024
Inflammation activation, particularly related to negative affectivity, may mediate the association between Type D personality and coronary plaque vulnerability in CAD patients.
Yi et al. (2022) conducted a cross-sectional in Coronary artery disease (n=347). Type D personality vs. Non-type D personality was evaluated on Mediating effect of standardized inflammation sumscore on the relationship between type D personality and plaque rupture vulnerability (effect size 0.16, 95% CI 0.043-0.365, p=.024). Type D personality was associated with increased inflammation, which mediated its relationship with coronary plaque rupture vulnerability (effect size 0.16; 95% CI 0.043-0.365; P=0.024).
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