Key result
Male hypertensive rats exhibited markedly increased superoxide anion production compared to females (30.9% vs 12.3%; p<0.05), driven by AT-1-dependent overexpression of NAD(P)H-oxidase components.
Population
Male and female spontaneously hypertensive rats (SHR)
Comparison
Treatment with DPI (NADH-oxidase inhibitor) or… vs Male vs. female SHR; untreated controls
Design
Preclinical
Authors
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Hypothesis-generating for sex-specific oxidative stress in hypertension; leaves open translation to human therapies pending further study.
Absolute Event Rate: 30.9% vs 12.3%
p-value: p=<0.05
Male spontaneously hypertensive rats exhibit higher basal superoxide anion concentration than females due to AT-1-dependent overexpression of NAD(P)H-oxidase components, suggesting a mechanism for gender differences in cardiovascular disease.
Ana Paula Dantas (2003) studied Hypertension (animal model). Male sex vs. Female sex was evaluated on Hydroethidine oxidation (superoxide anion production) (p=<0.05). Male hypertensive rats exhibited markedly increased superoxide anion production compared to females (30.9% vs 12.3%; p<0.05), driven by AT-1-dependent overexpression of NAD(P)H-oxidase components.
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