Key result
Dowex-50W-H catalyzed the highly selective desialylation of polysialylated gangliosides, yielding 60-70% GM1 among recovered lipids.
Dowex-50W-H provides a simple, nonenzymatic method for highly selective desialylation of polysialylated gangliosides to produce GM1.
Answers are grounded in this paper and cite their sources.
Enables selective GM1 production from polysialylated gangliosides; leaves open translation to mammalian or clinical applications.
Dowex-50W-H was used to catalyze the highly selective desialylation of polysialylated ganglio-N-tetraose series gangliosides to yield primarily GM1. High performance thin-layer chromatographic analysis of recovered lipid indicated that 60-70% of the recovered ganglioside was GM1. Identification of the major product as GM1 was confirmed by proton NMR spectra and lack of sialic acid release by Vibrio cholerae sialidase.-Schengrund, C-L., and P. Kov . A simple, nonenzymatic method for desialylating polysialylated ganglio-N-tetraose series gangliosides to produce GM1.
No takes yet. Share an insight, caveat, or question.
Schengrund et al. (1999) studied this question. Dowex-50W-H catalyzed desialylation was evaluated on Yield of GM1. Dowex-50W-H catalyzed the highly selective desialylation of polysialylated gangliosides, yielding 60-70% GM1 among recovered lipids.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: