Prognostic value of summed motion score assessed by gated SPECT myocardial perfusion imaging in patients with dilated cardiomyopathy

Figures

• 

  Figure 1. Wall motion and wall thickening analysis in two typical cases of the survivor group and the cardiac death group, respectively. (A) The wall motion (mm), wall thickening (%), wall motion score and wall thickening score of a 72-year-old male patient in the survivor group. SMS = 13, STS = 9. (B) The wall motion (mm), wall thickening (%), wall motion score and wall thickening score of a 65-year-old male patient in the cardiac death group. SMS = 63, STS = 39.

• 

  Figure 2. Screening for variables using the LASSO regression model. (A) Results of the Lasso regression. The 10 colored lines marked by Arabic numerals represent 10 different variables, lines 1–10 represented LVEFecho, SMS, STS, EDV (ml), ESV (ml), LVEF (%), PBW (°), Mean, PSD (°), and PE, respectively. By the LASSO regression, three variables (SMS, ESV and mean) were finally selected from the 10 variables. (B) LASSO coefficient profiles of the 10 prognostic factors for cardiac death. The optimal value of λ was determined by 10-fold cross-validation to find the minimum mean squared error (minMSE) + 1 standard error of minMSE backwards along the λ path.

• 

  Figure 3. Relationship between SMS and LVEF. A significant inverse correlation was observed between SMS and LVEF (r = −0.917, P < 0.001).

• 

  Figure 4. Incremental association between clinical variables (Clin), conventional LV function parameters (con LV), SMS and cardiac death as indicated by the statistics in serial multivariable adjusted models. Clinical variables include age, gender, BMI, Hypertension, Diabetes, Hyperlipidemia, QRS duration and NYHA class. LV index included EDV, ESV, LVEF, STS, Mean and PE.

• 

  Figure 5. The Kaplan-Meier event-free survival curve.

• 

  Figure 6. Time-independent receiver operating characteristic (ROC) curve. (A) ROC curve of SMS in different time. (B) ROC curve of LVEF in different time. (C) the AUC of SMS and LVEF in different time.