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NS2/3 protease remains a candidate antiviral target; leaves open clinical validation in HCV therapy.
NS2/3 has been proposed to function as a cysteine protease and, although shown to be required for HCV genome replication and persistent infection, the role of NS2/3 cleavage in the viral life cycle has not yet been fully investigated. Recent studies are beginning to clarify roles of the cleaved NS2 protein in modulation of host cell gene expression and apoptosis.
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Sarah Welbourn (2007) studied this question.
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