Population
Hepatitis C virus NS3-NS4A precursor expressed in Escherichia coli
Comparison
Interaction with NS4A vs NS3 alone (upon dissociation of NS4A)
Design
Preclinical
Authors
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NS4A's protease activation with helicase uncoupling merits antiviral target exploration; extends biochemical mapping but leaves open in vivo validation.
NS4A acts as an essential cofactor for NS3 protease activity but uncouples its ATPase/ssRNA binding and RNA unwinding activities.
Gallinari et al. (1999) studied this question.
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